Figure 2. (IMAGE)

Osaka University

Figure 2.

Caption

During DC migration, lysosomes are localized to the posterior part of the cell, and the Ragulator complex on the lysosome interacts to MPRIP, which anchors myosin light-chain phosphatase (MLCP) to actin filaments via MYPT1. The interaction between the Ragulator complex and myosin phosphatase Rho-interacting protein (MPRIP) interferes with the interaction between MPRIP and myosin phosphatase-targeting subunit 1 (MYPT1) to release the inhibiting role of MLCP in actomyosin contraction. As a result, actomyosin contraction occurs via phosphorylation of MLC, allowing immune cells to migrate.

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Osaka University

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