Model of FEN1 Protein with DNA (IMAGE)

DOE/Lawrence Berkeley National Laboratory

Model of FEN1 Protein with DNA

Caption

During DNA replication of the lagging strand, numerous Okazaki fragments must be joined. The newer fragment ends in a short flap call the 3’ overhang, while the previous fragment leaves a long 5’ flap after its primer is removed. The junction opens when the template strand is bent 100 degrees. FEN1 grasps the DNA at the bend, threads the flap through an archway, and trims the flap to match the overhang.

Credit

Susan Tsutakawa, Lawrence Berkeley National Laboratory

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