From Disorder to Order in FEN1 (VIDEO)

DOE/Lawrence Berkeley National Laboratory

Caption

Much of the FEN1 structure was solved by Sakurai et al, but how FEN1 works was not apparent in the DNA-free structure. The presence of DNA appears to induce the transition from disorder to order; FEN1 positions the 5’ flap and the 3’ overhang mainly by grasping the double-strand portions of DNA on either side of the 100-degree junction.

Credit

Susan Tsutakawa, Lawrence Berkeley National Laboratory

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