Fig. 2 MondoA counteracts cellular senescence in aging and ischemic AKI in humans (IMAGE)

Osaka University

Fig. 2 MondoA counteracts cellular senescence in aging and ischemic AKI in humans

Caption

Immunostaining images of MondoA and the senescence marker p21 in kidney biopsy samples from young and aged individuals, and from ischemic acute kidney injury (AKI) patients. In kidneys from aged individuals and ischemic AKI patients, the number of p21-positive cells (right, brown) was higher compared with young individuals, and this was accompanied by decreased expression of MondoA (left, brown) in the nucleus (purple).

Credit

2022 Yamamoto-Imoto et al. Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis. Cell Reports

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.