Metformin prolongs survival in a ND-CKD (Alport syndrome) mouse model, and is enhanced when combined with losartan (IMAGE)

Kumamoto University

Metformin prolongs survival in a ND-CKD (Alport syndrome) mouse model, and is enhanced when combined with losartan

Caption

Left: Administration of metformin or losartan to model mice significantly prolonged survival.

Right: Combined administration of low dose metformin and losartan significantly prolonged the survival of mice at doses where metformin alone does not show any effect.

Credit

Professor Hirofumi Kai

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<p>Adapted from Fig. 7 of <a href="https://www.nature.com/articles/s41598-021-86109-1" target="_blank"> Omachi, K. et.al., Scientific Reports, 2021</a>. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">CC by 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>

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