Formation of Collagen IV Trimer and Its Monitoring System (IMAGE)

Kumamoto University

Formation of Collagen IV Trimer and Its Monitoring System

Caption

(A) Collagen IV α3, α4, and α5 normally form trimers and become constituents of the basement membrane in the kidney. In Alport Syndrome, genetic mutation in one of the chains disrupts trimer formation. (B) By fusing collagen chains to Nanoluciferase fragments, it is possible to assess trimer formation of α3, α4, and α5 by luminescence intensity.

Credit

Assoc. Prof. Tsuyoshi Shuto

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