Deregulated mTOR-TFEB Axis Could Be An Effective Target for Kidney Stone Formation (IMAGE)

Nagoya City University

Deregulated mTOR-TFEB Axis Could Be An Effective Target for Kidney Stone Formation

Caption

During kidney stone development, mTOR is activated and nuclear TFEB expression is suppressed, impairing autophagy. Ablation of autophagy causes accumulation of damaged organelles. This enhances the inflammatory response, which facilitates crystal-cell interactions and promotes kidney stone formation. Therefore, autophagy defect caused by deregulation of the mTOR-TFEB axis could be an effective target for kidney stone formation. An mTOR inhibitor, TFEB inducer, or autophagy inducer could suppress the development of kidney stones.

Credit

Takahito Yasui, M.D., Ph.D.

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