LOCKR Human-Made Protein Switch (IMAGE)

University of Washington School of Medicine/UW Medicine

LOCKR Human-Made Protein Switch

Caption

LOCKR is a molecular switch made of multiple interacting parts: a 'key' (black) unlocks a 'cage' (grey), revealing a bioactive peptide (yellow) which can interact with other molecules in the cell. LOCKR, a synthetic protein complex, was computationally designed from scratch, then tested in living cells.

Credit

Ian Haydon, UW Medicine Institute for Protein Design

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