Overview of experiments (IMAGE)
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Overview of the experiments: Variant calls from long read–based and large-scale sequencing studies were used to construct pangenome reference graphs (top). Giraffe (and competing mappers) mapped reads to the graph or to linear references, and mapping accuracy, allele coverage balance, and speed were evaluated (middle). Then, mapped reads were used for variant calling, and variant call accuracy was evaluated (bottom). Structural variant calls were analyzed alongside expression data to identify eQTLs and population frequency estimates.
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Credit: Sirén et al., Science 2021
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