Anticancer drug resistance mechanism (IMAGE)

Kumamoto University

Anticancer drug resistance mechanism

Caption

Extracellular vesicle (EV) Annexin A6 secreted by cancer-associated fibroblasts (CAFs) is taken up by gastric cancer cells. Annexin A6 is involved in the acquisition of anticancer drug resistance by stabilizing β1 integrin present on gastric cancer cell membrane and then activating downstream signals.

Credit

Dr. Takatsugu Ishimoto

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