Formation of Collagen IV Trimer and Its Monitoring System (IMAGE)

Kumamoto University

Formation of Collagen IV Trimer and Its Monitoring System

Caption

(A) Collagen IV alpha-3, alpha-4, and alpha-5 normally form complexes (trimers) and become constituents of the basement membrane in the kidney. In Alport Syndrome, genetic mutation in one of the chains disrupts trimer formation. (B) By fusing collagen chains to Nanoluciferase fragments, it is possible to assess trimer formation of alpha-3, alpha-4, and alpha-5 by luminescence intensity.

Credit

Dr. Kohei Omachi

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