COVID-19 and dysregulation (IMAGE)

Pennington Biomedical Research Center

COVID-19 and dysregulation

Caption

Dysregulation of the physiological adaptation to changes and the modulatory effects of exercise. Psychological stress as may occur with COVID-19 activates the hypothalamic-pituitary-adrenal (HPA) axis, the autonomic nervous system, and the immune system. A dysregulated and overactive HPA axis drives sympathetic nervous system activation and an exaggerated immune response that promotes insulin resistance and β-cell dysfunction. Exercise contributes toward enhanced immunosurveillance and reduced inflammation to improve mental health outcomes and glycemic control

Credit

Dr. Candida Rebello

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