In-Frame and Out-Of-Frame Translation on the Same mRNA at the Same Time (IMAGE)

Hubrecht Institute

In-Frame and Out-Of-Frame Translation on the Same mRNA at the Same Time

Caption

Translation of mRNAs by multiple ribosomes at once, both in-frame and out-of-frame. Upper part shows translation as observed through the microscope. The mRNA is visualized in red, the in-frame translation in blue (MoonTag), and the out-of-frame translation in green (SunTag). Right panel shows an overlay of MoonTag and SunTag. One mRNA (arrow) is translated both in-frame (blue) as well as out-of-frame (green). The bottom panel shows a schematic of an mRNA that is translated in-frame by multiple ribosomes and out-of-frame by one ribosome.

Credit

Sanne Boersma and Deepak Khuperkar © Hubrecht Institute

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