Argonaute -- the Slicing Element in RNA Interference (IMAGE)

Cold Spring Harbor Laboratory

Argonaute -- the Slicing Element in RNA Interference

Caption

Structural biologists led by CSHL's Leemor Joshua-Tor obtained this view at atomic resolution of the human Argonaute protein. The brown-colored structure at the bottom is a portion of the GW182 protein that latches on to Argonaute, promoting their binding. This is an essential step in the process through which RNA interference (RNAi) silences gene expression.

Credit

Joshua-Tor Lab, CSHL

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