Uptake Went Up (IMAGE) Picower Institute at MIT Caption APOE4 Astrocytes showed an increase in endocytosis after overexpression of PICALM. In the bottom row, astrocytes (labeled blue), have taken up more of a protein called transferrin (labeled white). Credit Tsai Lab/MIT Picower Institute Usage Restrictions with credit License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.