Figure 2 (IMAGE)

Nagoya City University

Figure 2

Caption

USP17 regulates c-Myc-dependent cell proliferation and glycolysis. A. PC-3 cells and PC-3/FLAG-c-Myc cells were transiently transfected with the indicated siRNAs. After 72 h, cell viability was measured by a WST-8 cell proliferation assay. Results are shown as means ± S.D. (n=3). B, C. The medium from the PC-3 cell culture or PC-3/FLAG-c-Myc cell culture was collected for the analysis of glucose consumption (B) and lactate production (C). Results are shown as means ± S.D. (n=3). D. In cancer cells, a deubiquitinating enzyme, USP17 accumulates c-Myc protein to promote cell proliferation and glycolysis.

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Nagoya City University

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