Fig.2 Cancer-secreted hsa-miR-940 Induces Osteoblastic Lesions in the Bone Microenvironment (IMAGE)

Tokyo Medical and Dental University

Fig.2 Cancer-secreted hsa-miR-940 Induces Osteoblastic Lesions in the Bone Microenvironment

Caption

miR-940-overexpressing MDA-MB-231 breast cancer cells were established and implanted on the calvarial bones of immunodeficient mice. Interestingly, although MDA-MB-231 cells are commonly known to induce osteolytic phenotype, the implantation of miR-940-overexpressing cells induced extensive osteoblastic lesions in the resulting tumors by facilitating the osteogenic differentiation of host mesenchymal cells.

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Department of Physiology and Cell Biology,TMDU

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