De novo Damaging Mutations (IMAGE) NIH/National Institute of Mental Health Caption Seemingly disparate and scattered throughout the genome, spontaneous, or de novo, damaging mutations found in people with schizophrenia (red) clustered within genes forming a suspected disrupted network in the prefrontal cortex, thought to impair formation of new neurons during prenatal development. Credit Mary-Claire King, Ph.D., University of Washington Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.