De novo Damaging Mutations (IMAGE)

NIH/National Institute of Mental Health

De novo Damaging Mutations

Caption

Seemingly disparate and scattered throughout the genome, spontaneous, or de novo, damaging mutations found in people with schizophrenia (red) clustered within genes forming a suspected disrupted network in the prefrontal cortex, thought to impair formation of new neurons during prenatal development.

Credit

Mary-Claire King, Ph.D., University of Washington

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