Schematic overview (IMAGE)

Niigata University

Schematic overview

Caption

If the mitochondria are damaged (b) and/or autophagy-lysosome functions are impaired (c), the mitochondrial DNA persists in the cytosol and exerts toxic effects via the IFI16 protein leading to Parkinson's Disease pathogenesis. However, mitochondrial DNA should be rapidly degraded under normal conditions (a) or if DNAse II is upregulated to counteract the dsDNA deposits.

Credit

Matsui et al., Nat Commun. 2021

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