Cas9 and Guide RNA with DNA (IMAGE)

DOE/Lawrence Berkeley National Laboratory

Cas9 and Guide RNA with DNA

Caption

Upon binding with guide RNA, the two structural lobes of Cas9 reorient so that the two nucleic acid binding clefts face each other, forming a central DNA binding channel that interfaces with target DNA.

Credit

Image courtesy of Doudna, Nogales, et. al

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