Inhibition of LSD1 Activity in Adulthood Counteracts the Effects of Setd1a Deficiency (IMAGE)

The Zuckerman Institute at Columbia University

Inhibition of LSD1 Activity in Adulthood Counteracts the Effects of Setd1a Deficiency

Caption

Representative images of axon branching of WT (normal) mice (left) compared to SETD1A-deficient mice (left center). SETD1A-deficient mice injected with an LSD1 inhibitor (right center) rescued axonal growth to near-normal levels and counteracted the behavioral deficits. The LSD1 inhibitor had no effect on WT mice (right).

Credit

Jun Mukai/Gogos lab/Columbia's Zuckerman Institute

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