Upregulation of the Dopaminergic Pathway Following Focused Ultrasound-Facilitated Drug Delivery (IMAGE)

Columbia University School of Engineering and Applied Science

Upregulation of the Dopaminergic Pathway Following Focused Ultrasound-Facilitated Drug Delivery

Caption

The dopaminergic pathway can be downregulated similar to Parkinson's disease in toxin-based mouse models. Application of focused ultrasound results in increased blood-brain barrier permeability allowing the diffusion of pharmacological agents in the brain. Depending on the number of administrations and the delivery vehicle, the deliverable compounds can have beneficial effects of varying degree.

Credit

Maria Eleni Karakatsani/Columbia Engineering

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Please credit as: Maria Eleni Karakatsani/Columbia Engineering

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