SNIPR Graphic (IMAGE)
Caption
SNIPRs are RNA-based structures capable of identifying point mutations that can affect human health. The upper slide shows a SNIPR whose exposed section of RNA binds with a cell's healthy RNA, seen on the left. Here the SNIPR remains in the OFF position and no protein is produced. On the upper right side, the SNIPR encounters a mutant RNA. Here, binding causes the SNIPR to unfold, exposing the ribosome which reads the sequence and translates the RNA message into protein. The lower slide shows a sample of patient RNA spotted onto a paper based system, which displays a color change when mutant RNA is detected by the SNIPR.
Credit
Alex Green
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