Schematic Diagram of Cas9 mRNA Delivery in Vitro and in Vivo (IMAGE)

Tufts University

Schematic Diagram of Cas9 mRNA Delivery in Vitro and in Vivo

Caption

Lipids formulated with a bioreducible linker form the wall of nanoparticles encapsulating the mRNA of Cas9 plus sgRNA. Upon entering the cell, in vitro or in vivo, the linkers are broken and the particles disintegrate for delivery of contents and translation of mRNA into active enzyme for CRISPR/Cas9 genome editing

Credit

Qiaobing Xu, Tufts University

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