Figure 1. (IMAGE)

Osaka University

Figure 1.

Caption

The novel mouse model that reproduces the inter-tumor oncogene heterogeneity of liver tumors and discovery of high susceptibility of FGF19-driven tumors to lenvatinib treatment: By simultaneously introducing multiple oncogenes into hepatocytes, we created a new mouse model that randomly activates these oncogenes to develop liver cancer with high intertumor heterogeneity. Applying lenvatinib treatment to this model significantly reduced the proportion of tumors expressing the FGF19 gene compared to the untreated group, revealing that liver cancer with high FGF19 expression is highly sensitive to lenvatinib.

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Osaka University

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