Cascade (VIDEO) DOE/Lawrence Berkeley National Laboratory This video is under embargo. Please login to access this video. To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Caption This movie shows the structure of Cascade, a key protein comlpex in the microbial immune system. Here, the conformation of Cascade’s subunits - CasA (purple), CasB (yellow) and CasE (magenta) – are shown being rearranged while the helical spine of the complex remains relatively undisturbed. Credit Jennifer Doudna/Eva Nogales research groups, Berkeley, CA Usage Restrictions permission from Jennifer Doudna or Eva Nogales License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.