Gasdermin D and IL-1 Secretion (IMAGE)

Boston Children's Hospital

Gasdermin D and IL-1 Secretion

Caption

In hyperactivated macrophages, gasdermin D forms a limited number of pores -- enough to release IL-1 but not enough to kill the cell through pyroptosis. The macrophages stay alive and retain their phagocytic capacity, continuing to ingest microbes while stimulating memory T-cell formation via IL-1. Other proteins, like the cytokine TNF-alpha, are released through the classic secretion-signal pathway.

Credit

Charles Evavold, Boston Children's Hospital

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Please credit Charles Evavold, Boston Children's Hospital

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