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Caption
Polymeric micelles were one of the first polymer self-assemblies reported as a nano-DDS, and are composed of distinct two domains, a drug-loading core and a hydrophilic shell. Amphiphilic block copolymers, containing a hydrophilic block and a hydrophobic block, are firstly revealed to construct those distinct domains in a micelle structure through spontaneous self-assemble as a result of hydrophobic interactions in aqueous. H. Cabral, K. Miyata, K. Osada, K. Kataoka, "Block copolymer micelles in nanomedicine applications" Chem. Rev. 2018, 118 6844-6892. (DOI: 10.1021/acs.chemrev.8b00199)
Credit
2021 Innovation Center of NanoMedicine
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