Aggressive, Metastatic Breast Tumor, Pre-Treatment (IMAGE)
Caption
In preclinical tests in mice, a team at CSHL was able to dramatically change the character of an aggressive, metastatic primary breast tumor by targeting a single long non-coding RNA called Malat1 with a candidate drug called an antisense oligonucleotide (ASO). This image: Section of what doctors call an undifferentiated breast tumor -- densely packed with cancerous cells and with a high potential to spread. Next image: When treated with an antisense drug that specifically targets and reduces levels of Malat1, such tumors in mice were observed to undergo a change of character. The tumor becomes differentiated, its cells now cyst-like and filled with fluid that contains, among other things, milk proteins. The treated tumors were comparatively static, their metastatic activity reduced some 70 percent, the team reports.
Credit
Spector Lab, CSHL
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