Increasing Resolution in Genome Folding Heatmaps (IMAGE)

University of Pennsylvania

Increasing Resolution in Genome Folding Heatmaps

Caption

When the same linear DNA sequence is divided into different sized segments to analyze its 3-D conformation, different chromatin folding patterns emerge. In this image, the same region around the Sox2 gene is divided into 3, 9, 30, and ~250 bins. The Penn researchers' approach allows us to divide this region into ~250 bins, thus providing a relatively 'high resolution' snapshot of the 3-D conformation of the DNA.

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University of Pennsylvania

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