CRISPR Cpf1-Mediated Mutant Mouse (IMAGE)

Institute for Basic Science

CRISPR Cpf1-Mediated Mutant Mouse

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Cpf1 CRISPR knocked out genetic functions in Foxn1 (a transcription factor that regulates the immune system, including the growth of skin hairs), as well as Tyr (an enzyme that catalyzes the production of melanin, a natural pigment that determines the color of skin) The mutations may result in hairless and white-haired mouse respectively. Figure 3b shows a schematic of Cpf1 RNP delivery to a mouse embryo by electroporation.

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Institute for Basic Science

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