Breast Tissue Comparison (IMAGE)

University of Washington

Breast Tissue Comparison

Caption

This comparison shows images of breast tissue taken by the open-top light-sheet microscope (left), traditional pathology techniques (middle) and frozen sectioning during surgery (right). The first two images reveal crisp details of cellular and nuclear features, while the frozen-section image is distorted due to the challenges of freezing fatty breast tissues. While the formalin-fixed paraffin-embedded section requires hours of preparation, the open-top light-sheet microscope image is captured in minutes.

Credit

Glaser et al., Nature Biomedical Engineering

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