Image that Revealed New Brain Organization Principle (IMAGE)

Cold Spring Harbor Laboratory

Image that Revealed New Brain Organization Principle

Caption

Pavel Osten's team used their qBrain brain-mapping platform to visualize and count inhibitory neurons in the mouse brain. Brainwide distribution of the 3 major inhibitory cell types, expressing neuropeptides called SST, PV and VIP, is shown in this color-coded composite. These images revealed an unexpected cortical organizing principle: sensory-motor areas are dominated by output-modulating PV+ interneurons, while association areas are dominated by input-modulating SST+ interneurons. Other views revealed that despite their smaller size, female brains had more interneurons than male brains in most subcortical areas.

Credit

Osten Lab, CSHL

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