Mutation Signatures, by Age, Location and Disease Status (IMAGE)

Boston Children's Hospital

Mutation Signatures, by Age, Location and Disease Status

Caption

In these graphs, the number of mutations per neuron are grouped by age for each mutation category (similar ages are grouped by color). The circles represent individual neurons from the normal prefrontal cortex (PFC); triangles represent the normal dentate gyrus; diamonds denote neurons from people with neurodegenerative disease: Cockayne syndrome (CS) or xeroderma pigmentosa (XP). Signature A strongly correlates with age, regardless of disease status or brain region, while Signatures B and C do not.

Credit

Reprinted with permission from MA Lodato et al., <i>Science</i> Dec. 7, 2017, DOI: 10.1101/221960

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