Chart of Stiffness in Different Cell Types (IMAGE)

University of Pennsylvania

Chart of Stiffness in Different Cell Types

Caption

(Left) Collagen and lamin-A levels scale with cell stiffness, consistent with matching tissue stress to nuclear mechanics. (Right) Matrix stiffness in tissue culture increases cell tension and stabilizes lamin-A, regulating its own transcription and that of stress fiber genes, enhancing differentiation. RA, retinoic acid, i.e., vitamin A; RARG, YAP1, and SRF, transcription factors.

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Joe Swift, University of Pennsylvania

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