Blocking Interaction (IMAGE) University of Tokyo Caption Researchers at the University of Tokyo studied a cell membrane receptor, LRP1, and an enzyme, tPA, for their roles in metastasis of melanoma in mice. Mice without LRP1 had smaller tumors, even when excess tPA was given. OE = over expression, KD = knockdown. B16F1 = mouse melanoma skin cancer cells Credit Salama et al, originally published by FASEB Journal. CC-BY-NC Usage Restrictions Image by Salama et al, originally published by FASEB Journal. CC-BY-NC License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.