Figure 2. (IMAGE)

Osaka University

Figure 2.

Caption

Geographic mapping of subclones based on multi-region whole-exome sequencing and proposed clonal evolution of a pancreatic neuroendocrine carcinoma (Panc-NEC) in an autopsied patient. Proposed clonal evolution model according to the evolutional lineage tree based on the variant allele frequency of the mutations (LICHeE) in 20 primary regions and five liver metastases. The numbers inside the circles indicate mutations used by LICHeE to infer the subclonal structure. The colors in each subdivision describe the mutation groups characterizing cells in this subpopulation. The numbers and colors inside the squares indicate the region numbers shown in and composition of subpopulations, respectively. Macroscopic view of a section of the largest part of the primary Panc-NEC. Different areas are marked with colors corresponding to the predicted subclones based on the evolutional lineage tree. Microscopic view of region 12 of the primary Panc-NEC (H&E staining). Copy number analysis demonstrated that whole genome duplication occurred in only the adjacent regions 12, 16, and 17. An adenocarcinoma component was observed together with NEC only in region 12. NEC, NEC component; Ad., adenocarcinoma component. Pie chart showing the relationship between mutations detected in plasma cell free DNA and in tissue samples (20 primary regions and five liver metastases).

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©2021 Shinichi Yachida et al., Cancer Discovery

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