CD72 Specifically Inhibits Activation of Self-Reactive B Cells Pathogenic in Lupus (IMAGE)

Tokyo Medical and Dental University

CD72 Specifically Inhibits Activation of Self-Reactive B Cells Pathogenic in Lupus

Caption

The RNA-protein complex Sm/RNP, which is released from dead cells, stimulates B cells capable of producing anti-Sm/RNP antibody (anti-Sm/RNP B lymphocytes). The resulting anti-Sm/RNP antibody induces development of systemic lupus erythematosus (SLE) by forming immune complex together with Sm/RNP. In this study, the authors demonstrated that the B lymphocyte inhibitory receptor CD72 specifically inhibits activation of anti-Sm/RNP B lymphocytes by binding to Sm/RNP, thereby preventing development of SLE

Credit

Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University(TMDU)

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.