Dynamin in Action (IMAGE)
Caption
Scientists studying dynamin use an artificial membrane (orange) to analyze the protein's action. In the first image, dynamin has squeezed the membrane to create two vesicle-like structures (lower right). In the second image, taken seconds later, dynamin has severed the membrane to release these structures.
Credit
From Ramachandran R*, Pucadyil T.J.*, Liu Y.W., Acharya S., Leonard M., Lukiyanchuk V., Schmid S.L. 2009. Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. <i>Mol Biol Cell</i>. 2009 20:4630-9. (* The first two authors contributed equally.)
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