TAK1 Mechanism (IMAGE)

Osaka University

TAK1 Mechanism

Caption

This is the mechanism of vascular maintenance by endothelial TAK1. TAK1 maintains vascular integrity of the blood vessels by ensuring endothelial cell (EC) survival against TNFα induction by inflammation, gut microbe activity, or tumor presence. TAK1 deficiency results in EC death, leading to vascular dysfunction, hemorrhage, and rapid death of the animal.

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Osaka University

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