Gut Microbes (IMAGE)

Osaka University

Gut Microbes

Caption

Gut microbes and inflammation induce vascular destruction and hemorrhage in endothelial TAK1-deficient (TAK1ECKO) mice. TAK1 inhibition causes tumor regression. (A) Intestine of TAK1ECKO mouse with or without antibiotics. Intestinal bleeding was attenuated with antibiotics. (B) Lungs of TAK1ECKO and wild-type mice showing acute inflammation. Destruction of blood vessels and hemorrhage occurred in TAK1ECKO mice. Immunostaining shows induction of TNFα (red) by acute inflammation and destruction of endothelial cells (green) in TAK1ECKO mice. (C) Lewis lung carcinoma (LLC) tumor in a wild-type mouse, treated with TAK1 inhibitor. (D) Tumor volume in (C) before and after treatment with TAK1 inhibitor.

Credit

©Naito et al., 2019, Developmental Cell 48, 1-16. DOI: 10.1016/j.devcel.2018.12.002

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.