Figure 2 (IMAGE)

Osaka University

Figure 2

Caption

Schematic view of the role of Smurf2 in BMP/Smad signaling in wild type and Smurf2-deficient mice. In wild type mice, Smurf2 inhibits the bone morphogenetic protein (BMP)/Smad pathway by ubiquitinating Smad 1/5/8. The absence of Smurf2 in the Smurf2-deficient mice causes the BMP/Smad pathway to be activated.

Credit

<i>Bone Research</i> (Springer Nature) ISSN 2095-6231 (online)

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