Slit Overexpression Promotes V-SVZ-Derived Neuroblast Migration In The Injured Brain (IMAGE)
Caption
Left: Intact brain. Middle: Post-stroke brain. Astrocytes are activated in and around the lesion, which inhibit neuroblast migration. Neuroblasts use Slit protein to clear the path of activated astrocytes through the transmembrane receptor Robo, but the number reaching the lesion is insufficient to induce functional recovery. Right: Slit overexpression in the post-stroke brain. Slit-overexpressing neuroblasts migrate efficiently toward the lesion through activated astrocytes, resulting in functional recovery.
Credit
@Kazunobu Sawamoto
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