Figure 3 STAT3 can be a therapeutic target of chronic active EBV infection (CAEBV). (IMAGE)

Tokyo Medical and Dental University

Figure 3 STAT3 can be a therapeutic target of chronic active EBV infection (CAEBV).

Caption

STAT3 was constitutively activated in EBV-positive T- or NK-cells (EBV-T/NK-cells) from CAEBV patients. Jak inhibitors suppressed STAT3 activation leading to growth inhibition, enhanced apoptosis, and reduced cytokine production in EBV-T/NK-cells. These results indicated that STAT3 could be a therapeutic target in CAEBV.

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Department of Laboratory Molecular Genetics of Hematology,TMDU

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