The Glycan Gate Opens (IMAGE)

University of California - San Diego

The Glycan Gate Opens

Caption

The glycan gate opens: Supercomputing-driven simulations depict the glycan N343 (magenta) acting as a molecular crowbar to pry open the SARS-CoV-2 spike’s receptor binding domain, or RBD (cyan), from a “down” to an "up" position.

Credit

Terra Sztain, Surl-Hee Ahn, Lorenzo Casalino (Amaro Lab, UC San Diego)

Usage Restrictions

Illustrates Nature Chemistry paper: 'A glycan gate controls opening of the SARS-CoV-2 spike protein'

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