Mechanism of Inhibitory Synapse Formation Regulated by Synaptic Protein MDGA1 (IMAGE)

DGIST (Daegu Gyeongbuk Institute of Science and Technology)

Mechanism of Inhibitory Synapse Formation Regulated by Synaptic Protein MDGA1

Caption

Neurexins (orange) at the presynapse and Neuroligin at the postsynapse mediate synaptic development by binding two neurons through interactions. In inhibitory synapses, the regulatory protein MDGA1 produces a Neuroligin-2 (NL2) / MDGA1 complex based on strong binding power to Neuroligin-2 / Neurexin and effectively inhibits the development of inhibitory synapse by selectively interferes with binding of Neuroligin-2/Neurexin.

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DGIST

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