Two-Cell Embryos Contemplating Cell Fate (IMAGE) University of California - San Diego Caption Bioengineers at UC San Diego have determined through single-cell-RNA-sequencing that embryonic mouse cells show differences in gene expression as early as the two-cell stage of development. In this illustration evoking the 'opposite but interconvertible halves of Yin and Yang,' a two-cell embryo is showing signs of differentiating into a fetus and placenta, the first major task for an embryo. Credit Art by Victor O. Leshyk, published in Genome Research November 2014, 24(11). Usage Restrictions with credit License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.