Illustrating the roles of TLR3 signaling in alveolar bone resorption. (IMAGE)

Tokyo University of Agriculture and Technology

Illustrating the roles of TLR3 signaling in alveolar bone resorption.

Caption

TLR3 signaling activated by ds RNA [poly(I:C)] analogue induces the PGE2-mediated expression of RANKL that stimulates osteoclast formation and directly prolongs the life span of mature osteoclasts, that was leading alveolar bone resorption in periodontal disease.

Credit

Masaki Inada, Tokyo University of Agriculture and Technology

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