LTBR - Engineered CAR T Cells and Regular CAR T Cells Mixed With CD19+ Blood Cancer Cells (VIDEO)
Caption
Time lapse of engineered T cells (white/black) and blood cancer cells (green) imaged every 2 hours for 5 days. Human primary T cells were engineered with a Kymriah like chimeric antigen receptor (CAR) coexpressing either a control gene (left, Regular CAR T Cells) or with LTBR (right, Enhanced CAR T Cells). Engineered T cells were mixed with CD19+ blood cancer cells at a low dose. At the same dose/ratio, the LTBR enhanced CAR T cells eliminate the cancer cells whereas the control (regular) CAR T cells fail to control cancer cell growth.
Credit
Mat Legut/Jahan Rahman
Usage Restrictions
None
License
Original content