Schematic drawing the model of Olig2-mediated inhibition of p53 pathway (IMAGE)
Caption
It has been reported that Olig2 represses p53 transcriptional activation through suppression of p53 acetylation and inhibition of p53 target gene expression (bottom). In this study, we show that Olig2 promotes proper splicing of Mdm2 mRNA and p53 degradation by stabilizing Ddx20 and SMN complexes (top). Thus, we demonstrate that the Olig2 transcription factor also influences RNA metabolic processes.
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Niigata University
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